Stem cells were isolated from the umbilical cord matrix and grown in culture for 14 days. At this stage most cells in the population are at the mature megakaryocyte stage and can start producing platelets in internal membranes present in their cytoplasm. In this footage (images taken at a frequency of one image per minute), we observe the formation and spontaneous release of platelets using Nanolive’s 3D Cell Explorer.
Being able to image such processes in living megakaryocytes and without the constraints imposed by fluorescent probes, opens the door towards more complicated mechanistic studies of in vitro platelet generation.
Nanolive would like to thank the team at the Transfusion Research Center (TReC) – Belgian Red Cross-Flanders for preparing the samples.
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Automated live cell imaging: a unique walk-away solution for long-term live cell imaging of single cells and cell populations