Nanolive for Higher Education

3D Cell Explorer: the perfect live cell imaging tool for your experimental cell biology classes

Bring your Practical Courses to the Next Dimension

 

3D EXPLORATION OF LIVING CELLS

Explore cells in their natural state: alive and in 3D over time

UNIQUE LABEL-FREE DISCOVERY

Bypass tedious sample preparation to observe multiple organelles in a single image

INTERACTIVE EXPERIMENTS & LEARNING

Hands-on and collaborative experience for your students

BRIDGE THE GAP BETWEEN COURSEWORK AND RESEARCH

Inspire the scientists of tomorrow

 

“It’s fantastic to get our students to throw some cells onto a slide, stick it under a microscope and you’ve got a three-dimensional image with no staining, no toxic chemicals or anything. It’s perfect for undergraduate teaching.“

Dr. Chris Young, De Montfort University, Leicester, United Kingdom

At Nanolive, we focus on innovative product development at the highest standards to deliver a high precision and quality research device for our international customers.

Nanolive High Presicion since 2013

At Nanolive, we focus on innovative product development at the highest standards to deliver a high precision and quality research device for our international customers.

Bring your practical courses to the next dimension

Label-free Discovery

Perform label-free non-invasive accurate and quantitative 3D morphological monitoring of living single cells and cell cultures at every second.

Mouse fibroblast animation in 3D

On the first image you can find a 2D slice from the RI map of a mouse fibroblast. The small images show its internal compartments (a. nucleus + nuclear membrane, b. lipid droplets, c. lysosomes, d. plasma membrane, e. nucleoli, f. mitochondria). The animation shows the 3D reconstruction of the mouse fibroblast.

 

3D Exploration of Living Cells

Provide your students the unique advantage to observe living cells in their true nature and avoid misconceptions about cellular structures. Instead of working with dead, stained cells with traditional methods, with the 3D Cell Explorer, students explore living cells in 3D which offers a more accurate representation of reality.

Mitochondria imaged with the 3D Cell Explorer, label-free in living cells
Bean shaped mitochondria as depicted in textbooks

Comparison of living cells v.s. textbook images. Left: mitochondria imaged with the 3D Cell Explorer, label-free, in living cells, represented by long tubular structures. Right: bean-shaped mitochondria as depicted in textbooks.

Interactive Experiments & Learning

Enhance your courses with dynamic practical lessons. Students can study cells right from the dish and observe the complete cell life cycle processes of growth, division and death in 3D and 4D.

Stem Cells mitosis - label-free live cell imaging
Stem Cells mitosis - label-free live cell imaging - side view
Stem Cells mitosis - label-free live cell imaging
Stem Cells mitosis - label-free live cell imaging - side view

 

Long Term Live Imaging of Mouse Embryonic Stem Cells

User Interface STEVE - software for live cell imaging

With the integrated software STEVE, perform measurements (size & volume), export movies and 3D animations. Visualize different compartments of the cells with digital staining. Results and images can be shared among students and instructors to support assignments.

Bridge the Gap between Courswork & Research

The 3D Cell Explorer’s non-invasive technology allows your students to observe living samples in 3D at high magnification and with a 200 nm resolution (3-10x higher than compound light microscopes) in less than 2 seconds. Being a label-free imaging tool, the 3D Cell Explorer measures the physical properties of a cell (i.e. its Refractive Index) – with no staining required. A top-notch research tool available for undergraduate teaching at an affordable price with the added bonus of saving costs on reagents!

Case Study: EPFL’s Discovery Learning Labs (DLL)

The EPFL is one of Europe’s most dynamic and international science and technology institutions. Since beginning of 2019, it is the first university in Switzerland to include the 3D Cell Explorer in practical lab sessions through the Discovery Learning Labs (DLL). The DLL provides the opportunity to students to enjoy practical lab sessions from various different disciplines and to teach with the latest technologies.

Visit this link to read EPFL’S press release: https://actu.epfl.ch/news/the-world-of-3d-cells-is-now-open-for-epfl-student/.

Case Study: BSc Biomedical Science (BMS) under­graduate course at De Montfort University

The 3D Cell Explorer for the BSc Biomedical Science (BMS) undergraduate course at De Montfort University serves to observe live cell processes such as muscle contraction and autophagic cell death, and pathogens.

Dr. Chris Young’s undergraduate course are the first students in the UK to use the 3D Cell Explorer for Higher Education.

Applications

 Increase the learning potential for your undergraduate students with these significant applications.

Apoptosis live cell imaging - label-free
Cell Cycle Analysis 

Monitor every second of your cell’s life: from division to death.

Micro-Organisms

Unveil the secrets of the smallest living organism like Bacteria, Yeast, Protozoa & Diatoms and study their morphology and dynamics.

c.elegans
Model Organisms

Observe the most widely used model organisms in biomedical research – label-free and alive!

Technical Features 3D Cell Explorer 

Resolution Δx,y = 200nm; Δz = 400nm
Field of View 85 x 85 x 30 μm
Tomography frame rate 0.5 fps 3D image rate with full self-adjustement
Microscope Objective Air with 60x magnification
Illumination Source Class 1 laser low power
(λ=520 nm, sample exposure 0.2 mW/mm2)
Accessible Sample Stage 60 mm of free access to the sample stage for sample manipulation
Dimensions 38 cm x 17 cm x 45 cm
3D Cell Explorer - a label-free live cell imaging tool