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Synthetic oleanolic acid derivative, RTA‑408, overcome in TMZ‑resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest

Jul 21, 2025

Authors: Kuan‑Ting Lee, Ann‑Shung Lieu, Chih‑Lung Lin, Yi‑Chiang Hsu, Tai‑Hsin Tsai https://doi.org/10.1007/s12032-025-02875-2, 2025 Published in: Medical Oncology Tags: TMZ; omaveloxolone; glioblastoma; resistance

Design, Anticancer Activity, and Mechanistic Evaluation of a Novel Class of Selective Human Carbonic Anhydrase IX Inhibitors Featuring a Trifluorodihydroxypropanone Pharmacophore

Jun 30, 2025

Authors: Nicolino Pala, Federico Ladu, Wojciech Szlasa, Roberta Cadoni, Carrie Lomelino, Brian P. Mahon, Mitchell Gulkis, Robert McKenna, Alessandro Dessì, Roberto Dallocchio, Antonio Demelas, Mauro Carcelli, Dominga Rogolino, Claudia Crosio, Ciro Iaccarino, Julita...

Omaveloxolone Suppresses Cell Growth and Causes Cell Cycle Arrest by Downregulating CDC20 Expression in Glioblastoma Cells Both In Vitro and In Vivo

May 30, 2025

Authors: Kuan-Ting Lee, Yi-Chiang Hsu, Ann-Shung Lieu, Chih-Lung Lin, Tai-Hsin Tsai https://doi.org/10.1111/jcmm.70607, 2025 Published in: Journal of Cellular and Molecular Medicine Tags: CDC20; cell cycle; glioblastoma; Nrf2; omaveloxolone

Yuanhuacine suppresses head and neck cancer growth by promoting ASCT2 degradation and inhibiting glutamine uptake

May 16, 2025

Authors: Xin-yi Chen, Xin Chen, Xiao-hui Liang, Dong Lu, Rong-rong Pan, Qing-yi Xiong, Xiao-xia Liu, Jia-yi Lin, Li-jun Zhang, Hong-zhuan Chen, Jin-mei Jin, Wei-dong Zhang, Xin Luan https://doi.org/10.1038/s41401-025-01562-2, 2025 Published in: Acta Pharmacologica...

The correlation of immunotoxicity with size and chemical properties of particulate matter within macrophages

May 2, 2025

Authors: Hsiang-Yu Kung, Yi-Shiuan Wang, Yung-Jui Chen, Ting-Hsuan Wu, Jai-Yu Chen, Yueh-Feng Wen, Yu-Cheng Chen, Hong-Lin Chan, Hsiu-Chuan Chou https://doi.org/10.1016/j.cbpc.2025.110215, 2025 Published in: Comparative Biochemistry and Physiology Part C: Toxicology...
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