Design, Anticancer Activity, and Mechanistic Evaluation of a Novel Class of Selective Human Carbonic Anhydrase IX Inhibitors Featuring a Trifluorodihydroxypropanone Pharmacophore

Authors: Nicolino Pala, Federico Ladu, Wojciech Szlasa, Roberta Cadoni, Carrie Lomelino, Brian P. Mahon, Mitchell Gulkis, Robert McKenna, Alessandro Dessì, Roberto Dallocchio,
Antonio Demelas, Mauro Carcelli, Dominga Rogolino, Claudia Crosio, Ciro Iaccarino, Julita Kulbacka, Daniela Vullo, Fabrizio Carta, Claudiu T. Supuran, Mario Sechia

https://ssrn.com/abstract=5311733, 2025

Published in: SSRN

Tags: Carbonic Anydrases; hCA IX isoform; trifluorodihydroxypropanones; anticancer agents; X-ray co-crystals