PNPLA3-I148M is a neomorph that interferes with two primary hepatic triglyceride clearance pathways

Authors: David J. Sherman∙ Lei Liu ∙ Edward L. La ∙ Preston Fordstrom ∙ Danielle Pruitt ∙ Jose Barreda ∙ Joy G. Cagmat ∙ Jiansong Xie ∙ John Ferbas ∙ Ingrid C. Rulifson, ∙ Raymond J. Deshaies

https://doi.org/10.1016/j.celrep.2025.116371

Published in: Cell reports (2025)

Tags: Lipid droplets, secretory pathway
lipolysis
polyunsaturated fatty acids
phospholipid
triglyceride
membrane fluidity, steatoic liver disease