Scientific Publications
Peer-reviewed research using Nanolive imagingDiscover a list of peer-reviewed scientific publications using Nanolive imaging in the fields of drug discovery, cell metabolism, etc.
Displaying 89 results:
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Feature Application: Live T Cell Assay
The Live T Cell Assay promises to accelerate the advancement of basic cell biology and of novel, safe, and effective immunotherapies. The goal of this application note is to show some of the potential uses of the Live T Cell Assay and hopefully, inspire research that will increase the success rate of anticancer drug development. To this end, we present the first in-depth investigation of bispecific antibodies using the Live T Cell Assay.
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Feature Application: Multiparametric cytotoxicity assays
This Feature Application shows the huge potential that Nanolive imaging holds for the drug discovery process, where cytotoxicity remains one of the major causes of drug withdrawal, and there is an urgent need for reliable and time-saving assay workflows. Our first case study features an in-depth investigation of the dynamics of cell death following exposure to seven cell death stimuli: extreme shifts in external pH, thermal stress, phototoxicity, oxidative stress, Shikonin, Ebastine, and Taxol. Our second case study shows that we can quantify drug-dependent and dose-dependent effects in 96-well plate format.
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Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy
Authors: Paola Bonaventura; Vincent Alcazer; Virginie Mutez; Laurie Tonon; Juliette Martin; Nicolas Chuvin; Emilie Michel; Rasha E. Boulos; Yann Estornes; Jenny Valladeau-Guilemond; Alain Viari; Qing Wang; Christophe Caux; Stéphane Depil
https://doi.org/10.1126/sciadv.abj3671, 2022
Published in: Science Advances
Tags: adaptive immunity; Human endogenous retroviruses; cancer vaccine; immunotherapy; solid tumors
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AlPc/ZnPc-based oncological photodynamic therapy for a selective eradication of leukemic cells from ovarian tissue
Authors: Saeid Moghassemi; Arezoo Dadashzadeh; Paulo Eduardo Narcizode Souza; Ricardo Bentes Azevedo; Christiani A. Amorim
https://doi.org/10.1016/j.pdpdt.2021.102555, 2021
Published in: Photodiagnosis and Photodynamic Therapy
Tags: Photodynamic therapy; cancer therapy; photosensitizer; ovarian transplantation; leukemia; phthalocyanine; photoimmunotherapy
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P2RY12-Inhibitors Reduce Cancer-Associated Thrombosis and Tumor Growth in Pancreatic Cancers
Authors: Ana Luisa Palacios-Acedo; Soraya Mezouar; Diane Mège; Lydie Crescence; Christophe Dubois; Laurence Panicot-Dubois
https://doi.org/10.3389/fonc.2021.704945, 2021
Published in: Frontiers in Oncology
Tags: pancreatic tumors; thrombosis; clopidogrel; aspirin; P2Y12 receptor
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Berberine photo‐activation potentiates cytotoxicity in human astrocytoma cells through apoptosis induction
Authors: Francesca Carriero; Carolina Martinelli; Fabio Gabriele; Giulia Barbieri; Lisa Zanoletti; Gloria Milanesi; Claudio Casali; Alberto Azzalin; Federico Manai; Mayra Paolillo; Sergio Comincini
https://doi.org/10.3390/jpm11100942, 2021
Published in: Journal of Personalized Medicine
Tags: oxidative stress; phyto-therapy; astrocytoma; glial tumor
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Label-free quantitative phase imaging reveals spatial heterogeneity of extracellular vesicles in selected colon disorders
Authors: Łukasz Zadka; Igor Buzalewicz; Agnieszka Ulatowska-Jarża; Agnieszka Rusak; Maria Kochel; Ireneusz Ceremuga; Piotr Dzięgiel
https://doi.org/10.1016/j.ajpath.2021.08.005, 2021
Published in: The American Journal of Pathology
Tags: digital holographic tomography; extracellular vesicles; Evs; colorectal cancer; ulcerative colitis
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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
Authors: Deborah Fanfone; Zhi Chong Wu; Jade Mammi; Kevin Berthenet; David Neves; Kathrin Weber; Andrea Halaburkova; François Virard; Félix Bunel; Hector Hernandez-Vargas; Stephen WG Tait; Ana Hennino; Gabriel Ichim
https://doi.org/10.7554/eLife.73150, 2022
Published in: eLife
Tags: metastasis; invasion; anoikis; cancer; motility; evasion; resistance
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Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis
Authors: Rui Zan; Hao Wang; Weijie Cai; Jiahua Ni; Bérengère J. C. Luthringer-Feyerabend; Wenhui Wang; Hongzhou Peng; Weiping Ji; Jun Yan; Jiazeng Xia; Yang Song; Xiaonong Zhang
https://doi.org/10.1016/j.bioactmat.2021.07.026, 2021
Published in: Bioactive Materials
Tags: Biodegradable magnesium; hydrogen; tumor apoptosis; underlying mechanism; P53
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Significant difference in response of malignant tumor cells of individual patients to photodynamic treatment as revealed by digital holographic microscopy
Authors: A.A. Zhikhoreva; A.V. Belashov; A.B. Danilova; N.A. Avdonkina; I.A. Baldueva; M.L. Gelfond; T.L. Nekhaeva; I.V. Semenova; O.S. Vasyutinskii
https://doi.org/10.1016/j.jphotobiol.2021.112235, 2021
Published in: Journal of Photochemistry and Photobiology B: Biology
Tags: Digital holographic microscopy; photodynamic treatment; phase images; malignant cells; individual patients