Glioblastoma: the most aggressive brain cancer Glioblastoma multiforme (GBM) is an aggressive brain tumor that places among the most lethal of cancers. Unfortunately, most patients with GBMs die of their disease in less than a year and long-term survival prospects are...
What is Cdk2 and why is it an attractive anti-cancer target? Cyclin-dependent kinase 2 (Cdk2) plays an important role in the cell cycle, regulating the transition from the G1 phase where the cell grows and certain intracellular components (such as the centrosomes)...
Background In this case study, we expose cells to inhibitors or modulators of kinase activity and observe how the cells respond. Hyperactivity, malfunction or overexpression of kinases is the root cause of many human cancers, and so the development of kinase...
