Noninvasive phenotypic screening
for Alzheimer’s markers in microglia
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September 15th, 2026
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How can label-free phenotypic profiling reveal links between metabolic function and Alzheimer’s disease pathogenesis? Join us to learn how Dr Kimberley Bruce’s team at the University of Colorado Anschutz used label-free live-cell phenotyping to identify early disease-relevant cellular changes and connected them to mechanisms of microglial metabolic dysfunction in Alzheimer’s disease.
Sharing work recently accepted by the journal Alzheimer’s and Dementia, Dr Bruce will explore quantitative phenotypic readouts for live microglial cells, lipid droplets, and mitochondria to shed light on the effects of ApoE4, the strongest genetic risk factor for Alzheimer’s disease, in particular, how ApoE4 affects the metabolic reprogramming of microglia.
Mitochondria and lipid droplets are among the earliest indicators of changing cell health, stress, and therapeutic response, but neurodegenerative disease models pose additional difficulties due to the sensitivity of cells to chemical probes and fluorescent imaging techniques. Dr Bruce will also discuss the field’s technical limitations and share her experience pioneering Nanolive’s unique label-free technology to characterize a neurodegenerative disease model for Alzheimer’s.
This online event is ideal for scientists working in neuroscience, metabolic disease, and phenotypic screening who are looking to:
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- Identify neurodegenerative disease-relevant phenotypes in sensitive live-cell models
- Connect microglial morphology, mitochondria, and lipid droplet dynamics to mechanisms of dysfunction
- Study ApoE4-driven metabolic reprogramming in an Alzheimer’s disease model
- Move beyond endpoint assays by capturing dynamic cellular responses over time
- Preserve fragile cell behavior with label-free imaging and reduced phototoxicity
- Generate scalable, quantitative readouts to support more reproducible phenotypic screening
This event will be available online at the following times:
September 15 at 4 pm CEST/ 10 am EDT / 7 am PDT
September 15 at 10 pm CEST/ 4 pm EDT / 1 pm PDT
September 16 at 1 am CEST/ September 15 at 7 pm EDT / September 15 at 4 pm PDT
Duration: 35 minutes
Host and Speakers
Hope Amos
Scientific Communication Manager
Nanolive
Dr Kimberley Bruce
Associate Professor
University of Colorado Anschutz